Bone marrow monocytes sustain NK cell-poiesis during non-alcoholic steatohepatitis.

Natural killer (NK) cells are the predominant lymphocyte population in the liver. At the onset of non-alcoholic steatohepatitis (NASH), an accumulation of activated NK cells is observed in the liver in parallel with inflammatory monocyte recruitment and an increased systemic inflammation. Using in vivo and in vitro experiments, we unveil a specific stimulation of NK cell-poiesis during NASH by medullary monocytes that trans-present interleukin-15 (IL-15) and secrete osteopontin, a biomarker for patients with NASH.

Use of vitamin K antagonist therapy in geriatrics: a French national survey from the French Society of Geriatrics and Gerontology (SFGG).

Objective: We aimed to evaluate the quality and determinants of vitamin K antagonists (VKA) control among very elderly patients in geriatric settings.

Methods: A national cross-sectional survey was conducted among patients aged ≥80 years who were hospitalized in rehabilitation care or institutionalized in a nursing home and who were treated by VKA. Time in therapeutic range (TTR) was computed according to Rosendaal's method.

[Frailty in older population: a brief position paper from the French society of geriatrics and gerontology].

Frailty in the older population is a clinical syndrome which evaluate a risk level. The Frailty syndrome defines a reduction of the adaptation capacity to a stress. It can be modulated by physical, psychological and social factors.

Preliminary reliability study of the affective lability scale adapted for adolescents in a francophone clinical population.

Objective: to study the reliability of a self-questionnaire on adolescent affective instability, within a francophone clinical population.

Method: After reviewing the literature and consulting experts, the Affective Lability Scale (ALS), developed by Harvey and collaborators (1989), was selected. An anglophone and francophone version, adapted for the adolescent population, was developed.

Exploring sleep disturbances in adolescent borderline personality disorder using actigraphy: a case report.

Actigraphy has been used in clinical pediatric populations for many years, including attention deficit-hyperactivity disorder and mood disorders to characterize circadian rhythms of motor activity, and as an alternative evaluation of sleep patterns. We present a case of an adolescent presenting with borderline personality disorder (BPD) and substance dependence for whom an investigation of sleep patterns using actigraphy and a sleep diary appeared to be useful in managing the case. Actigraphy contributed to the diagnostic clarification and disconfirmed the relevance of prescribing medication to this patient for sleep problems.