Development and validation of a rapid capillary electrophoresis method for the determination of oseltamivir phosphate in Tamiflu and generic versions.

A rapid and reliable capillary zone electrophoresis method was developed and validated for the assay of oseltamivir phosphate in capsules. Separation was carried out in fused silica capillary (60.2 cm total length and 10.

Development and validation of a rapid HPLC method for the determination of oseltamivir phosphate in Tamiflu and generic versions.

Oseltamivir phosphate (OP) is an antiviral drug that is used in the treatment and prophylaxis of both influenza A and influenza B. It is effective against all known influenza viruses than can infect humans, including pandemic influenza viruses and may be the most appropriate antiviral option against avian influenza caused by H5N1 virus. Tamiflu, the registered trademark used under exclusive license by Roche laboratories with OP as active pharmaceutical ingredient, is considered the best treatment for the bird flu disease.