Publications by authors named "H Bone"
This article aims to outline the fundamental principles of consultations with and clinical assessments of patients with symptoms that may be indicative of respiratory system pathology. The article explores how to perform a respiratory system-focused patient history and physical examination. An evaluation of clinical 'red flags' to reduce the risk of omitting serious illness is also considered, alongside the exploration of features of respiratory pathology and evidence-based clinical decision-making tools that may be used to support clinical diagnosis.
View Article and Find Full Text PDFArticle Synopsis
- Influenza virus activates the inflammasome pathways in cells, which can lead to both positive and negative effects on infection outcomes.
- The study shows that mice lacking the gasdermin D (GSDMD) protein experience less severe effects of influenza, such as less weight loss and lung damage, despite having similar levels of the virus.
- The research highlights that GSDMD plays a role in enhancing neutrophil responses during influenza infection, which worsens inflammation and lung damage, suggesting that targeting this protein could be a potential treatment for severe influenza cases.
Red algae or seaweeds produce highly distinctive halogenated terpenoid compounds, including the pentabromochlorinated monoterpene halomon that was once heralded as a promising anticancer agent. The first dedicated step in the biosynthesis of these natural product molecules is expected to be catalyzed by terpene synthase (TS) enzymes. Recent work has demonstrated an emerging class of type I TSs in red algal terpene biosynthesis.
View Article and Find Full Text PDFHypoxia, a state of insufficient oxygen availability, promotes cellular lactate production. Lactate levels are increased in lungs from patients with idiopathic pulmonary fibrosis (IPF), a disease characterized by excessive scar formation, and lactate is implicated in the pathobiology of lung fibrosis. However, the mechanisms underlying the effects of hypoxia and lactate on fibroblast phenotype are poorly understood.
View Article and Find Full Text PDFContext: Chronic hypoparathyroidism is conventionally treated with oral calcium and active vitamin D to reach and maintain targeted serum calcium and phosphorus levels, but some patients remain inadequately controlled.
Objective: To assess long-term safety and efficacy of recombinant human parathyroid hormone (1-84) (rhPTH(1-84)) treatment.
Methods: This was an open-label extension study at 12 US centers.