[E-Z ratio and stability of halogenated benzylidene derivatives formed during the detection of glycine conjugates].

The orange fluorescing spot formed during the detection of halogenated hippuric acids with 4-N,N-Dimethylaminobenzaldehyde on TLC-plates consists of a E/Z-mixture of the corresponding benzyliden derivatives. Intermediates are the azlactones.

[Cleavage and biotransformation of the central muscle relaxant chlormezanone].

Chlormezanone, a chiral centrally acting muscle relaxant, will be cleaved at its S-C-1 bond by an autoprotolytic process. The optimum of chemical stability exists between pH 2 up to pH 9 with a maximum at pH 7.4.

[Fast thin-layer densitometric determination of the nootropic piracetam in biological material].

After oral doses of piracetam this drug is detectable in serum as well as in urine after formation of the red Fe(III)-hydroxamatecomplex by thin-layer densitometry. Detection in serum requires extraction with a mixture of dichloromethane/ methanol, while urine can be used directly after dilution. The limit of quantification in urine is 100 micrograms/ml and in serum 4.