Publications by authors named "H Bisgaard"
Article Synopsis
- Genome-wide association studies have found numerous genetic loci linked to glycemic traits, but connecting these loci to specific genes and biological pathways remains a challenge.
- Researchers conducted meta-analyses of exome-array studies across four glycemic traits, analyzing data from over 144,000 participants, which led to the identification of coding variant associations in more than 60 genes.
- The study revealed significant pathways related to insulin secretion, zinc transport, and fatty acid metabolism, enhancing understanding of glycemic regulation and making data available for further research.
Background: In environmental bacteria, the selective advantage of antibiotic resistance genes (ARGs) can be increased through co-localization with genes such as other ARGs, biocide resistance genes, metal resistance genes, and virulence genes (VGs). The gut microbiome of infants has been shown to contain numerous ARGs, however, co-localization related to ARGs is unknown during early life despite frequent exposures to biocides and metals from an early age.
Results: We conducted a comprehensive analysis of genetic co-localization of resistance genes in a cohort of 662 Danish children and examined the association between such co-localization and environmental factors as well as gut microbial maturation.
Background: We previously showed an association between neonatal bacterial airway colonisation and increased risk of persistent wheeze/asthma until age 5 years. Here, we study the association with persistent wheeze/asthma and allergy-related traits until age 18 years.
Methods: We investigated the association between airway colonisation with , and/or in 1-month-old neonates from the COPSAC mother-child cohort and the development of persistent wheeze/asthma and allergy-related traits longitudinally until age 18 years using generalised estimating equations.
Article Synopsis
- The study investigates the link between sphingolipid metabolism and childhood asthma, focusing on how different classes of sphingolipids interact with asthma risk factors.
- Researchers analyzed blood samples from nearly 1,000 children to explore associations between sphingolipids, asthma, and specific risk factors like genetic markers, vitamin D levels, and gut health.
- The findings indicate that while overall sphingolipid levels correlate with asthma, specific subclasses (like ceramides) have distinct roles, with some linked to increased asthma risk factors rather than the disease itself.
Background: Blood eosinophil count is a well-established biomarker of atopic diseases in older children and adults. However, its predictive role for atopic diseases in preschool children is not well established.
Objective: To investigate the association between blood eosinophil count in children and development of atopic diseases up to age 6 years.