Background: Guideline-directed medical therapy for heart failure (HF) with reduced ejection fraction can entail high out-of-pocket (OOP) costs, prompting concerns about financial toxicity and access. OOP costs are generally unavailable during encounters. This trial assessed the impact of providing patient-specific OOP costs to patients and clinicians.
View Article and Find Full Text PDFThe aim of this study was to investigate the well-known selection bias favouring players born earlier in the year commonly referred to as the Relative Age Effect (RAE). Therefore, we analysed a group of top-tier youth academy players. The players joined and left the youth academy at different stages, where the first stage was at 8 years (U9) and the last stage was at 18 years of age (U19).
View Article and Find Full Text PDFThe concept of space has been successfully modelled in football using spatiotemporal player data and Voronoi diagrams. Current approaches, however, are narrow in scope by focusing on an inter-team allocation of space to measure space . The present work extends this widespread perspective with an intra-team application of the Voronoi diagram and its dual Delaunay triangulation to measure space .
View Article and Find Full Text PDFObjective: Systemic sclerosis (SSc) is a severe rheumatic disease causing fibrotic tissue rearrangement. Aberrant toll-like receptor (TLR) 8 transcripts in plasmacytoid dendritic cells (pDCs) were recently linked to SSc pathogenesis, which is at least partially mediated by increased type I interferon (IFN-I) responses. Here, we addressed the functional role of TLR8 signaling in different immune cell subsets of patients with SSc.
View Article and Find Full Text PDFThe majority of soccer analysis studies investigates specific scenarios through the implementation of computational techniques, which involve the examination of either spatiotemporal position data (movement of players and the ball on the pitch) or event data (relating to significant situations during a match). Yet, only a few applications perform a joint analysis of both data sources despite the various involved advantages emerging from such an approach. One possible reason for this is a non-systematic error in the event data, causing a temporal misalignment of the two data sources.
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