Paraoxonase 1 Activity, Polymorphism and Atherosclerosis Risk Factors in Patients Undergoing Coronary Artery Surgery.

Background: Paraoxonase1 (PON1), an enzyme connected to high density lipoproteins (HDL) particles, plays an important role in protecting arteries against atherosclerosis. The serum activity and concentration of PON1 depends on several genetic polymorphisms as well as environmental factors.

Materials And Methods: Investigated population consisted of 71 patients aged 43⁻76 years with confirmed coronary heart disease (CHD).

Dynamic changes of paraoxonase 1 activity towards paroxon and phenyl acetate during coronary artery surgery.

Background: Serum paraoxonase 1 (PON1), an enzyme associated with high - density lipoproteins (HDL) particles, inhibits the oxidation of serum lipoproteins and cell membranes. PON1 activity is lower in patients with atherosclerosis and in inflammatory diseases. The systemic inflammatory response provoked during cardiopulmonary bypass grafting may contribute to the development of postoperative complications.

Prognostic value of paraoxonase 1 in patients undergoing coronary artery bypass grafting surgery.

Background: The aim of this study was to evaluate whether -108C/T polymorphism of the paraoxonase 1 (PON1) gene and the plasma enzyme activity are risk factors for adverse cardiac events after coronary artery bypass grafting (CABG).

Material And Methods: Seventy-one patients with coronary heart disease (CHD) undergoing CABG were enrolled in the study. Genomic DNA was extracted from the venous blood using the Gen Elute™ Blood Genomic DNA kit (Sigma) according to the manufacturer's instructions.

Apoptosis of lymphocytes and sialic acid plasma level in patients undergoing cardiac surgery.

Increasing evidence shows that extensive tissue trauma and surgical stress are related to physical alterations of cells and cell death. It was previously reported that total sialic acid (SA) plasma concentration is elevated in patients undergoing coronary artery surgery. Shedding or secreting of SA from the cell membrane surface or releasing intracellular SA may induce apoptosis.

p53 protein accumulation in colorectal cancer tissue has prognostic value only in left-sided colon tumours.

Unlabelled: The aim of this paper is to describe the prospective 10-year follow-up study of prognostic value of p53 protein accumulation in cancer cells in relation to the localisation of tumour in colorectum.

Methods: The p53 protein accumulation has been assessed immunohistochemically in tumour tissue samples obtained from 80 selected sporadic colorectal cancer patients.

Results: p53 protein accumulation was detected more often in rectum than in colon tumours.