Inhibition of Vascular Endothelial Growth Factor Reduces Photoreceptor Death in Retinal Neovascular Disease via Neurotrophic Modulation in Müller Glia.

VEGF is not only the most potent angiogenic factor, but also an important neurotrophic factor. In this study, vitreous expression of six neurotrophic factors were examined in proliferative diabetic retinopathy (PDR) patients with prior anti-VEGF therapy (n = 48) or without anti-VEGF treatment (n = 41) via ELISA. Potential source, variation and impact of these factors were further investigated in a mouse model of oxygen-induced retinopathy (OIR), as well as primary Müller cells and 661W photoreceptor cell line under hypoxic condition.

The lightweight design of steel pistons for diesel engines based on thermo-mechanical characteristics.

Traditional aluminum-silicon alloy pistons are gradually replaced by steel pistons, which has become the trend of future diesel engine development. However, the efficient design and broad application of steel pistons are limited by the higher density of steel. For this reason, a new lightweight design method for steel pistons in diesel engines was proposed in this paper.

Metabolic-Immune Suppression Mediated by the SIRT1-CX3CL1 Axis Induces Functional Enhancement of Regulatory T Cells in Colorectal Carcinoma.

Metabolic reprogramming of tumor cells dynamically reshapes the distribution of nutrients and signals in the tumor microenvironment (TME), affecting intercellular interactions and resulting in metabolic immune suppression. Increased glucose uptake and metabolism are characteristic of many tumors. Meanwhile, the progression of colorectal carcinoma (CRC) relies on lipid metabolism.

Construction of MOF-derived Vanadium Nitride Decorated Micro/mesoporous Carbon Nanofibers for Aqueous Zinc-Ion Batteries.

Design and manufacture of cathode materials, with suitable pore structure and high electrical conductivity to matching zinc anode, solving the problem of dissolution and structural degradation of cathode materials for zinc ion batteries (ZIBs), is great significance to the development of ZIBs. Herein, Vanadium Nitride (VN) uniformly decorated N-doped micro/mesoporous carbon nanofibers (VN/N-MCNF) with appropriate porous and reactive sites for Zn2+ is prepared by using V-MOF, as important precursor via electrostatic spinning and pyrolysis technique. As a cathode electrode for ZIBs, the VN/N-MCNF is suitable for diffusion and adsorption of large-sized solvated structured [Zn(H2O)6]2+, for its abundant micro/mesoporous structure and good electrical conductivity.

The role of GOT1 in cancer metabolism.

GOT1, a cytoplasmic glutamic oxaloacetic transaminase, plays a critical role in various metabolic pathways essential for cellular homeostasis and dysregulated metabolism. Recent studies have highlighted the significant plasticity and roles of GOT1 in metabolic reprogramming through participating in both classical and non-classical glutamine metabolism, glycolytic metabolism, and other metabolic pathways. This review summarizes emerging insights on the metabolic roles of GOT1 in cancer cells and emphasizes the response of cancer cells to altered metabolism when the expression of GOT1 is altered.