Publications by authors named "H Benediktsson"

Background: In anti-neutrophil cytoplasmic antibody (ANCA)-associated vasculitis (AAV), histopathological assessment of affected tissue is often necessary for diagnosis and assessment of disease extent. There is a requirement for validated non-invasive biomarkers to avoid the need for serial tissue biopsies.

Methods: A systematic review of scientific databases from 2012 until present was performed to identify studies fulfilling the inclusion criteria.

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Article Synopsis
  • The study aimed to show that using the K114 fluorophore can effectively detect and differentiate between AL and AA types of renal amyloidosis compared to traditional methods.
  • Kidney biopsies from patients with different types of amyloidosis were stained and imaged, showing that K114 could clearly distinguish between normal tissue and both types of amyloid, while Congo Red had limitations and a higher chance of false positives.
  • The results indicate that K114 staining has potential for clinical use in diagnosing renal amyloidosis due to its superior specificity and ability to quantify differences between amyloid types.
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Metabolomics is a mainstream approach for investigating the metabolic underpinnings of complex biological phenomena and is increasingly being applied to large-scale studies involving hundreds or thousands of samples. Although metabolomics methods are robust in smaller-scale studies, they can be challenging to apply to larger cohorts due to the inherent variability of liquid chromatography mass spectrometry (LC-MS). Much of this difficulty results from the time-dependent changes in the LC-MS system, which affects both the qualitative and quantitative performances of the instrument.

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The mechanisms that drive leukocyte recruitment to the kidney are incompletely understood. Dipeptidase-1 (DPEP1) is a major neutrophil adhesion receptor highly expressed on proximal tubular cells and peritubular capillaries of the kidney. Renal ischemia reperfusion injury (IRI) induces robust neutrophil and monocyte recruitment and causes acute kidney injury (AKI).

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