Impact of Lupus Anticoagulant on INR Using Recombinant Prothrombin Time Reagent.

BACKGROUND Lupus anticoagulants (LA) can interfere with routine coagulation tests such as the activated partial thromboplastin time (aPTT) and prothrombin time (PT). The international normalized ratio (INR) is derived from PT and is used to monitor warfarin therapy. A positive LA result is one of the laboratory criteria of the 2023 ACR/EULAR antiphospholipid syndrome (APS) classification criteria.

Comparative Study between Two Adjacent Implants Supported Crowns and One Implant Supported Cantilever Fixed Dental Prosthesis: An Study.

Aim: To assess hard as well as soft peri-implant tissues within cases having two lost adjacent anterior teeth treated through placing either two implants with two separate crowns or only an implant along with a crown with a cantilever, and evaluating the effect of polyetheretherketone (PEEK) restoration on cantilever design up to 18 months after functional loading.

Materials And Methods: Twenty-seven participants (15 males and 12 females; mean age, 38.6 years; range 20-50 years) with missing two adjacent anterior teeth were treated with implant system (Flotecno implant system, Italy).

Characterization of NAT, GST, and CYP2E1 Genetic Variation in Sub-Saharan African Populations: Implications for Treatment of Tuberculosis and Other Diseases.

Tuberculosis (TB) is a major health burden in Africa. Although TB is treatable, anti-TB drugs are associated with adverse drug reactions (ADRs), which are partly attributed to pharmacogenetic variation. The distribution of star alleles (haplotypes) influencing anti-TB drug metabolism is unknown in many African populations.

Fracture resistance and mode of failure of modified Polyether-ether-ketone versus lithium disilicate endocrowns.

Purpose: The current study aimed to compare modified Polyether-ether-ketone's fracture resistance and failure mode versus lithium disilicate glass-ceramic endocrowns.

Materials And Methods: A total of 16 butt-joint endocrown specimens on mandibular second molar teeth were fabricated and divided into two equivalent groups; Pressable modified Polyether-ether-ketone (PEEK) (BioHPP) and Pressable lithium disilicate glass ceramic (IPS e.max Press).

Genetic Insights Into Epidermolysis Bullosa: Identification of Novel Variants in Tunisian Patients.

Epidermolysis Bullosa (EB) is a group of genetic skin disorders characterized by extreme skin fragility and blistering. In North African countries, including Tunisia, complex genetic and phenotypic diversity is entangled with a scarcity of scientific research on EB. This lack of knowledge presents a distinct challenge in terms of diagnostic accuracy and patient care.