Publications by authors named "H Bellon"
Article Synopsis
- SARS-CoV-2 infections have been confirmed in various nondomestic felids across multiple continents, including tigers, lions, and leopards, primarily between March 2020 and February 2021.
- The clinical signs in infected animals varied, with symptoms such as coughing and decreased appetite being common, although most felids recovered without serious complications, except for one older tiger who had to be euthanized due to severe health issues.
- Infection was often traced back to asymptomatic zookeepers, highlighting that cloth masks and gloves are likely ineffective at preventing the transmission of the virus from humans to these large cats.
Background: Insults to the airway epithelium play a key role in constrictive bronchiolitis after lung transplantation, the typical hallmark of chronic rejection. Our hypothesis is that immunosuppressives might affect airway integrity.
Methods: A biculture of human bronchial epithelial cells and lung microvascular endothelial cells was exposed to immunosuppressives (serum through levels) for 24 hours or 4 days.
High-dose vitamin D after lung transplantation: A randomized trial.
J Heart Lung Transplant
August 2017
Background: Vitamin D may have innate immunomodulatory functions with potentially beneficial therapeutic effects in lung transplant recipients.
Methods: This was a single-center, double blind, randomized, placebo-controlled, prevention trial of once-monthly oral vitamin D (cholecalciferol; 100,000 IU, n = 44) vs placebo (n = 43) during 2 years in adult lung transplant recipients enrolled from October 2010 to August 2013. Primary outcome was prevalence of chronic lung allograft dysfunction (CLAD) 3 years after transplantation.
Despite donor organ shortage, a large proportion of possible donor lungs are declined for transplantation. Criteria for accepting/declining lungs remain controversial because of the lack of adequate tools to aid in decision-making. We collected, air-inflated, and froze a large series of declined/unused donor lungs and subjected these lung specimens to CT examination.
View Article and Find Full Text PDFSurvival after lung transplantation is hampered by chronic lung allograft dysfunction (CLAD). Persistently elevated BAL-neutrophilia is observed in some patients despite treatment with azithromycin, which may be induced by IL-1α. Our aim is to establish an in vitro model, assess mechanistic pathways and test different therapeutic strategies of IL-1α-induced release of IL-8 by human bronchial epithelial cells.
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