[Pathophysiology of post-aggression metabolism].

The metabolic situation of the socalled "post aggression syndrome" related to operations or trauma is elucidated in terms of two out of three phases described by a working hypothesis. It is governed primarily by anti insulin factors and can be identified by the resulting catabolism. The leading phenomena are increased of general turnover rates, glycogenolysis, gluconeogenesis, lipolysis, and protein degradation.

Perfluorocarbone (FDA 20) and extracorporeal circuit of isolated extremity perfusion.

The applicability of Fluosol DA 20 as a perfusion fluid was investigated in the isolated limb perfusion of 14 mongrel dogs and its performance compared with that of diluted blood. Control of perfusion parameters permitted a direct comparison of the two perfusion liquids. Muscle tissue, blood and perfusate were analyzed for pH, pO2, pCO2, O2 content, lactate, pyruvate, ATP and creatine phosphate.

Comparative studies with Fluosol, Dextran, their mixture, or autologous blood in experimental hypovolemic shock.

In 42 rabbits blood pressure was held at 40 mmHg/15 min. Various treatments resulted in equal recovery from shock in 4 groups. There is, however, some evidence that: (1) Dextran 40 was superior regarding microcirculation; (2) Fluosol added more oxygen to the tissues; and (3) a combined treatment showed both effects.