Publications by authors named "H Beggs"

Article Synopsis
  • Metabolic activity is crucial for regulating macrophage function, with pro-inflammatory types favoring glycolysis and pro-repair types relying on oxidative processes.
  • This study investigates how the metabolism of alveolar macrophages (AM) in mice responds to LPS stimulation, compared to bone marrow-derived macrophages (BMDM).
  • Findings show that AM have higher oxygen consumption and fatty acid oxidation; when glutamine metabolism is inhibited, AM alter their metabolic activity and response to LPS differently than BMDM.
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Although sensor technologies have allowed us to outperform the human senses of sight, hearing, and touch, the development of artificial noses is significantly behind their biological counterparts. This largely stems from the sophistication of natural olfaction, which relies on both fluid dynamics within the nasal anatomy and the response patterns of hundreds to thousands of unique molecular-scale receptors. We designed a sensing approach to identify volatiles inspired by the fluid dynamics of the nose, allowing us to extract information from a single sensor (here, the reflectance spectra from a mesoporous one-dimensional photonic crystal) rather than relying on a large sensor array.

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Multi-decadal ocean time-series are fundamental baselines for assessing the impacts of environmental change, however, compiling and quality controlling historic data from multiple sources remains challenging. Here we aggregate, document, and release a number of long time-series temperature products and climatologies compiled from data obtained at 4 monitoring sites around Australia where sub-surface ocean temperature has been recorded nominally weekly to monthly since the 1940s/50s. In recent years, the sampling was augmented with data obtained from moored sensors, vertical profiles and satellite-derived data.

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Despite recent advances, acute respiratory distress syndrome (ARDS) remains a severe and often fatal disease for which there is no therapy able to reduce the underlying excessive lung inflammation or enhance resolution of injury. Metabolic programming plays a critical role in regulating inflammatory responses. Due to their high metabolic needs, neutrophils, macrophages, and lymphocytes rely upon glutamine metabolism to support activation and function.

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