Publications by authors named "H Bashir"
Commonly used adenine-induced chronic kidney disease (CKD) murine models often employ C57BL/6 mice; however, this strain has inherent limitations due to its natural resistance to developing key pathological features of CKD, such as tubulointerstitial fibrosis and inflammation. There have been attempts to overcome these barriers by using multiple concentrations of adenine-supplemented diets or by performing prolonged experiments up to 20 weeks. Here, we demonstrate that SKH1 Elite mice develop clinically relevant CKD phenotypes (e.
View Article and Find Full Text PDFThe immune system comprises various regulators and effectors that elicit immune responses against various attacks on the body. The pathogenesis of autoimmune diseases is derived from the deregulated expression of cytokines, the major regulators of the immune system. Among cytokines, interleukins have a major influence on immune-mediated diseases.
View Article and Find Full Text PDFBACKGROUND Second-degree atrioventricular (AV) block is a frequently encountered conduction abnormality on surface electrocardiogram (ECG). However, it does not always imply a block at the AV nodal level. In rare cases, this block can occur below the bundle of His, within the infra-Hisian region of the His-Purkinje system.
View Article and Find Full Text PDFArticle Synopsis
- There is currently no FDA-approved dedicated transcatheter heart valve specifically for treating native aortic regurgitation.
- Ongoing clinical trials and compassionate use experiences in the U.S. offer some outcomes data, focusing on echocardiographic and clinical results one year post-procedure.
- A case study of a 28-year-old man treated with the J-Valve in 2019 shows promising long-term (5-year) outcomes, suggesting it could be a viable minimally invasive option for high-risk patients.