Publications by authors named "H Baker"
New drugs for Duchenne muscular dystrophy (DMD) are emerging rapidly. However, we and others believe these drugs are achieving regulatory approval prematurely. It is the cardiorespiratory complications of DMD that cause the disease's major morbidities and that determine survival.
View Article and Find Full Text PDFBackground: Medical cannabis (MC) has gained traction in oncology for managing cancer-related symptoms, but its integration faces challenges due to limited evidence, inconsistent guidelines, and varied legal frameworks.
Methods: The TASMAN study aimed to assess the knowledge, attitudes, and practices of oncologists and palliative care providers globally regarding MC use in cancer care. A survey of healthcare providers from diverse regions and income levels was conducted.
Article Synopsis
- * A study using a human mutation library identified certain unstable mutations that predominantly rely on the ubiquitin proteasome system for degradation and found that the co-chaperones DNAJA1 and DNAJA2 interact significantly with one of the mutated proteins.
- * DNAJA2 plays a dual role: it stabilizes various normal proteins and specifically helps reduce the breakdown of some mutated proteins, highlighting how the protein quality control mechanisms adapt to handle misfolded proteins in the cytosol.
Article Synopsis
- This study presents a series of 16 cases using single-port robotic surgery to repair ureteroenteric anastomosis stricture (UES), marking the first documented success with this technique.
- A retrospective review was conducted on patients who underwent this procedure after radical cystectomy from September 2020 to July 2024, assessing demographics and surgical outcomes.
- Results showed that surgeries were accomplished with minimal complications, an average operation time of 265 minutes, and a low average hospital stay of 4.9 days, indicating that this technique is both safe and effective, though further research is recommended.