Engineering a membrane protein chaperone to ameliorate the proteotoxicity of mutant huntingtin.

Toxic protein aggregates are associated with various neurodegenerative diseases, including Huntington's disease (HD). Since no current treatment delays the progression of HD, we develop a mechanistic approach to prevent mutant huntingtin (mHttex1) aggregation. Here, we engineer the ATP-independent cytosolic chaperone PEX19, which targets peroxisomal membrane proteins to peroxisomes, to remove mHttex1 aggregates.

Association between Sarcopenic Obesity and Arterial Stiffness in Korean Adults.

: This study examined the association between sarcopenic obesity and arterial stiffness using bioelectrical impedance analysis (BIA). : This retrospective cross-sectional study included 20,601 Korean adults from January 2016 to December 2023. Sarcopenia was defined as height-adjusted appendicular skeletal muscle mass [(ASM/height) <5.

Similar, not universal: the cognitive dimensions of conceptual prototypes of basic emotions in English and in Polish.

The current study explores the differences in conceptualisation of the prototypical basic emotion lexicalisations (, , , , , ) in English and in Polish. Measures of concreteness, imageability and context availability were collected and analysed across the six semantic categories of basic emotions, across different parts of speech and between the self-determined genders of the study participants. The initial results indicate that within these cognitive dimensions the conceptualisations of basic emotions in English and in Polish are only similar on the more general but not the higher levels of conceptualisation.

Quantification method of ctDNA using cell-free DNA methylation profile for noninvasive screening and monitoring of colon cancer.

Background: Colon cancer ranks as the second most lethal form of cancer globally. In recent years, there has been active investigation into using the methylation profile of circulating tumor DNA (ctDNA), derived from blood, as a promising indicator for diagnosing and monitoring colon cancer.

Results: We propose a liquid biopsy-based epigenetic method developed by utilizing 49 patients and 260 healthy controls methylation profile data to screen and monitor colon cancer.

Quadriceps recovery and pain relief in knee osteoarthritis rats by cog polydioxanone filament insertion.

Quadriceps muscles play a pivotal role in knee osteoarthritis (OA) progression and symptom manifestation, particularly pain. This research investigates the therapeutic effectiveness of muscle enhancement and support therapy (MEST), a recently developed device intended for intramuscular insertion of cog polydioxanone filaments, in quadriceps restoration to alleviate OA pain. Knee OA was induced in Sprague Dawley rats via monoiodoacetate injections.