Publications by authors named "H BONNET"
Objective: To examine the characteristics of comparative non-randomised studies that assess the effectiveness or safety, or both, of drug treatments.
Design: Cross sectional study.
Data Sources: Medline (Ovid), for reports published from 1 June 2022 to 31 August 2022.
Objectives: Visual abstracts (VAs) lack study-specific reporting guidelines and are increasingly used as stand-alone sources in medical research dissemination although not designed for this purpose. Therefore, our objectives were to describe 1) completeness of reporting in VAs and corresponding written abstracts (WAs) of randomized controlled trials (RCTs), and 2) the extent and type of spin (ie, any reporting pattern that could distort result interpretation and mislead readers) in VAs and WAs of RCTs with a statistically nonsignificant primary outcome.
Study Design And Setting: We conducted a cross-sectional study evaluating VAs and WAs of RCTs published between January 1, 2021, and March 3, 2023.
Article Synopsis
- i-Motifs (iMs) are unconventional DNA structures that form in cytosine-rich sequences, primarily under acidic conditions, and have gained attention due to the development of a specific antibody, iMab, which aids in their study in live cells.
- Research shows that the interaction between iMab and cytosine-rich oligonucleotides relies on having at least two consecutive cytosines and is more pronounced in acidic pH, regardless of whether the sequence can form an iM structure.
- Bulk-FRET experiments indicate that iMab can cause the unfolding of iM structures and binds to segments of 2-3 cytosines in single-stranded DNA, suggesting that findings using this antibody
Article Synopsis
- Temperate trees enter a dormant state in winter to adapt to unfavorable conditions for growth, a process that involves complex signaling pathways and transport capacity between cells.
- Researchers used physiological, imaging, and transcriptomic methods to study how transport capacity influences dormancy in sweet cherry flower buds.
- Findings indicate that while transport capacity decreases during dormancy and is influenced by environmental signals, dormancy release is linked to the bud's readiness for growth, particularly in warmer temperatures, involving specific key genes.
G-quadruplex DNA structures (G4) are proven to interfere with most genetic and epigenetic processes. Small molecules binding these structures (G4 ligands) are invaluable tools to probe G4-biology and address G4-druggability in various diseases (cancer, viral infections). However, the large number of reported G4 ligands (>1000) could lead to confusion while selecting one for a given application.
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