The role of ABC transporter DrrABC in the export of PDIM in .

The virulence lipid phthiocerol dimycocerosate (PDIM) is exported by a complex mechanism that involves multiple proteins including the Resistance-Nodulation-Division (RND) transporter MmpL7 and the lipoprotein LppX. Here, we probe the role of the putative heterooligomeric ATP-Binding Cassette (ABC) transporter complex composed of DrrA, DrrB and DrrC in PDIM transport by constructing a set of individual null mutants of , and in the vaccine strain BCG. Loss of all three, or individual genes, all resulted in a complete loss of PDIM export to the outer envelope of the mycobacterial cell.

Efficacy of a gelling-fibre dressing and a gelling-fibre dressing with silver nanoparticles at controlling exudate and infection: a 4-week multicentre clinical evaluation.

Background: Suprasorb Liquacel Pro (standard test dressing) and Suprasorb Liquacel Ag (test dressing with silver nanoparticles) are absorptive gelling-fibre dressings designed to manage wound exudate levels and promote moist wound healing, with the latter having additional antimicrobial properties.

Aims: To assess the impact of the test dressing on healing, exudate levels and signs of infection.

Methods: Patients with moderately-to-highly exuding hard-to-heal wounds of any type were dressed with the standard test dressing or the test dressing with silver nanoparticles if they showed covert or overt signs of local infection.

For preschoolers, word knowledge falls on a continuum: A novel framework for capturing the incremental process of word learning.

In gaining word knowledge, children's semantic representations are initially imprecise before becoming gradually refined. We developed and tested a framework for a digital receptive vocabulary assessment that captured varied levels of representation as children learn words. At pre-test and post-test, children selected one of four images to match a word's meaning: a correct target, a conceptually-related foil, a thematically-related foil, and a phonologically-similar foil.

Becoming word meaning experts: Infants' processing of familiar words in the context of typical and atypical exemplars.

How do infants become word meaning experts? This registered report investigated the structure of infants' early lexical representations by manipulating the typicality of exemplars from familiar animal categories. 14- to 18-month-old infants (N = 84; 51 female; M = 15.7 months; race/ethnicity: 64% White, 8% Asian, 2% Hispanic, 1% Black, and 23% multiple categories; participating 2022-2023) were tested on their ability to recognize typical and atypical category exemplars after hearing familiar basic-level category labels.