Publications by authors named "H B Shrestha"
The identification of peptides is a cornerstone of mass spectrometry-based proteomics. Spectral library-based algorithms are well-established methods to enhance the identification efficiency of peptides during database searches in proteomics. However, these algorithms are not specifically tailored for tandem mass tag (TMT)-based proteomics due to the lack of high-quality TMT spectral libraries.
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- The study analyzed medication patterns for opioid use disorder (MOUDs) during pregnancies among a cohort of 3,911 expectant mothers with opioid use disorder (OUD) from seven clinical sites.
- It found that over 90% of pregnancies involving methadone were among publicly insured individuals, and there was an increasing usage of buprenorphine with naloxone and naltrexone in recent years.
- The research highlighted that most prenatal care and MOUD documentation occurred within the same trimester, but discontinuity in MOUD treatments across trimesters still existed, indicating a need for improved access to care during pregnancy.
The mode of transport of lignin monomers to the sites of polymerization in the apoplast remains controversial. C-Lignin is a recently discovered form of lignin found in some seed coats that is composed exclusively of units derived from caffeyl alcohol. RNA-seq and proteome analyses identified a number of transporters co-expressed with C-lignin deposition in the seed coat of Cleome hassleriana.
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- - The study analyzes age-dependent changes in the brain proteins and their modifications in several mouse models of Alzheimer's disease (AD), focusing on how these models represent human AD complexities.
- - Results showed that commonly used mouse models only replicate about 30% of the protein changes seen in humans, but adding more genetic factors can increase this to 42%.
- - The research highlights inconsistencies between protein and gene expression in the 5xFAD model, indicating that amyloid plaque environments affect protein turnover, which could lead to new targets for AD treatment.
Introduction: In 2018, the World Health Organization recognized traditional healers as community stakeholders in dementia care. This scoping review aimed to summarize the existing dementia care literature regarding strategies for the integration of traditional healing in dementia care and the roles of traditional healers.
Methods: A group of Indigenous Elders from Northern Ontario, Canada, guided, reviewed, and validated the research process and findings.