Publications by authors named "H B STEWART"
Introduction: Prehabilitation seeks to enhance functional capacity and preparedness before surgery with the aim of improving outcomes; it is generally based on exercise, diet and psychological interventions. While there is obvious appeal to this approach in terms of patient experience and resource use, the interventions are complex and the evidence base for prehabilitation before cancer surgery is heterogeneous. Prehabilitation requires patient understanding and motivation as well as commitment of resources.
View Article and Find Full Text PDFPositive allosteric modulation of the mu-opioid receptor is a promising strategy to address the ever-growing problem of acute and chronic pain management. Positive allosteric modulators (PAMs) of the mu-opioid receptor could be employed to enhance the efficacy of endogenous opioid peptides to a degree that provides pain relief without the need for traditional opioid drugs. Alternatively, PAMs might be used to enhance the action of opioid drugs and so provide an opioid-sparing effect, allowing for the use of lower doses of opioid agonists and potentially decreasing associated side effects.
View Article and Find Full Text PDFBackground: Infection during pregnancy with SARS-CoV-2 can have a serious impact on both maternal and foetal health. Clinical studies have shown that SARS-CoV-2 transmission from the mother to the foetus typically does not occur. However, there is evidence that SARS-CoV-2 can infect the placenta .
View Article and Find Full Text PDFArticle Synopsis
- The study examines the effects of e-cigarette use on lung function among young adults aged 18 to 24, comparing those exposed to e-cigarettes with those who are not.
- Participants were categorized based on their history of e-cigarette use, ranging from unexposed to heavy users, with ventilation distribution assessed using the lung clearance index (LCI).
- Results indicated that e-cigarette users, particularly heavy users, had higher LCI measures compared to unexposed individuals, suggesting that LCI could be a valuable biomarker for detecting early lung function impairment related to e-cigarette use.
Menstrual Suppression in Gender-Diverse Youth: What's Most Important to Patients?
J Pediatr Adolesc Gynecol
November 2024
Study Objective: To explore reasons for menstrual suppression method choice among transgender and gender-diverse (TGD) youth at the time of method initiation DESIGN, SETTING, AND PARTICIPANTS: A cross-sectional analysis of baseline data from a prospective cohort study of menstruating TGD youth (N = 55), aged 12-17 years, initiating a hormonal method for menstrual suppression in a gender health specialty clinic at a single site, quaternary hospital in the Midwest INTERVENTIONS AND MAIN OUTCOME MEASURES: Participants completed a baseline survey that included identifying the most important reason, as well as other important reasons, for menstrual suppression method selection.
Results: The mean age was 14.9 (SD 1.