Publications by authors named "H B Rosenblum"
Fetal alcohol spectrum disorders (FASDs) are characterized by a range of physical, cognitive, and behavioral impairments. Determining how temporally specific alcohol exposure (AE) affects neural circuits is crucial to understanding the FASD phenotype. Third trimester AE can be modeled in rats by administering alcohol during the first two postnatal weeks, which damages the medial prefrontal cortex (mPFC), thalamic nucleus reuniens, and hippocampus (HPC), structures whose functional interactions are required for working memory and executive function.
View Article and Find Full Text PDFAlthough invasive cervical cancer (ICC) rates have declined since the advent of screening, the annual age-adjusted ICC rate in the United States remains 7.5 per 100,000 women. Failure of recommended screening and management often precedes ICC diagnoses.
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- This study examined how interactions between the ventricles affect right ventricular (RV) size and function in patients with left ventricular assist devices (LVADs) during hemodynamic tests by varying the device speed.
- Researchers found that faster LVAD speeds led to an increase in RV end-diastolic volume and stroke volume, while RV end-systolic volumes remained stable.
- The results suggest that these interventricular interactions actually improve RV compliance and decrease afterload without impairing RV contractility, challenging the common belief that these interactions negatively affect RV function.
Article Synopsis
- * Out of 10 documented pregnancies during LVAD support, 8 resulted in successful births, while 1 case involved maternal and fetal mortality and another was a spontaneous abortion.
- * The study emphasizes the importance of a collaborative care approach, proper medication management, and understanding the physiological changes during pregnancy to support maternal and fetal health while on LVAD.
Article Synopsis
- COVID-19 vaccines are crucial for preventing severe outcomes, like hospitalization and death, but their effectiveness has been impacted by evolving variants.
- Since September 2022, bivalent mRNA vaccines were recommended, but they were tailored to variants that are no longer prevalent.
- As of September and October 2023, the FDA approved updated vaccines from Moderna, Pfizer-BioNTech, and Novavax to enhance immunity against currently circulating variants, with vaccination recommended for everyone aged 6 months and older.