Publications by authors named "H B Peterson"
Purpose: We aimed to describe SARS-CoV-2 lineages and diversity in children and adults in Estonia and similarity to travel-related cases and neighbouring countries.
Methods: SARS-CoV-2 sequences in 2021-2022 from a nationwide study were included. The proportion of predominant lineages in Estonian regions and among travel-related cases was described by multinomial logistic regression.
Article Synopsis
- Research indicates that structural and functional brain changes are linked to opioid use disorder (OUD), but earlier studies often had small participant groups, especially fewer women, and focused on single types of brain analysis.
- This study aimed to use comprehensive brain imaging techniques, including T1-weighted MRI and resting-state fMRI, to better identify these brain alterations in OUD patients undergoing methadone treatment compared to healthy controls.
- Results showed significant differences in brain volumes between the two groups, with OUD participants having smaller thalamus and temporal lobe sizes but larger brainstem and cerebellum volumes, and there were sex-based differences in the medial prefrontal cortex volumes.
Article Synopsis
- Major risk factors for urothelial cell carcinoma (UCC) include smoking and occupational exposures, but 30% of cases are still unexplained; pet dogs may serve as models for studying non-tobacco UCC risk due to their similar disease behavior.
- Researchers exposed human and canine urothelial cells to acrolein and inorganic arsenic to explore DNA damage, finding specific genotoxic thresholds for each substance.
- The study indicated that non-tobacco exposure to acrolein could lead to early DNA damage in both humans and dogs, warranting further investigation into these chemical exposures in relation to UCC.
Article Synopsis
- The study investigates how the surrounding DNA sequence affects the repair of double-stranded breaks caused by CRISPR/Cas9, using various genetically modified mouse embryonic stem cell lines.
- Researchers analyzed over 236,000 mutation outcomes from 2800 synthetic DNA sequences, discovering specific roles of DNA repair proteins like Prkdc and Polm in generating small insertions and deletions.
- They developed predictive models for these mutational outcomes based on their findings, enhancing the understanding of DNA repair mechanisms and enabling more accurate control of CRISPR-induced mutations.
Brachycephalic Obstructive Airway Syndrome (BOAS) is a potentially life-threatening condition that can be challenging to diagnose and grade objectively. The aim of this study was to investigate the use of respiratory signal analysis to assess severity of BOAS in dogs. Hundred and seventeen client-owned dogs of brachycephalic and non-brachycephalic breeds were enrolled.
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