Novel neo-clerodane diterpenoids from Teucrium quadrifarium and their anti-ferroptosis effect.

Teucrifarides A-D (1-4), four previously unreported neo-clerodane-type diterpenoids, combined with sixteen known analogs (5-20), were purified from Teucrium quadrifarium. The absolute forma of compounds 1-4 were determined via spectroscopic and ECD calculation methods, together with X-ray crystallography experiments. Among them, compound 1 possessed a 5,20-epoxy ring featuring a unique cage-like 12-oxatricyclo [5.

Distribution characteristics of Hg and As in the water-SPM system in the Xiaoqing river estuary and coastal.

Water and suspended particulate matter (SPM) were collected from Xiaoqing Estuary and its adjacent waters in August 2022 to study the spatial distribution and risk assessment of Hg and As. The content of Hg in SPM samples ranged from 4.7152 to 446.

Cross sectional associations of physical activity and sleep with mental health among Chinese university students.

Objective: This study aimed to examine the levels of physical activity (PA), sleep, and mental health (MH), specifically depression, anxiety, and stress, among Chinese university students. It also aimed to analyze the influencing factors of MH, providing a theoretical foundation for developing intervention programs to improve college students' mental health.

Methods: A stratified, clustered, and phased sampling method was employed.

Hepatocyte-Derived FGF1 Alleviates Isoniazid and Rifampicin-Induced Liver Injury by Regulating HNF4α-Mediated Bile Acids Synthesis.

Isoniazid and rifampicin co-therapy are the main causes of anti-tuberculosis drug-induced liver injury (ATB-DILI) and acute liver failure, seriously threatening human health. However, its pathophysiology is not fully elucidated. Growing evidences have shown that fibroblast growth factors (FGFs) play a critical role in diverse aspects of liver pathophysiology.