Possible interaction of platelets and adrenaline in the early phase of myocardial infarction.

It is known that in most cases of transmural acute myocardial infarction a platelet clot originates within a coronary artery. In acute myocardial infarction patients increased levels of the plasma catecholamines adrenaline and noradrenaline as well as the platelet release proteins platelet factor 4 and beta-thromboglobulin have been reported. In this study, significantly higher values were found of platelet factor 4 (P less than 0.

[Separation of a Beall Surgitool prosthesis disk 15 years after mitral valve replacement].

The case of a 46-year-old woman who survived disc embolization of a Beall Surgitool prothesis for 10 days is described. The patient presented to another hospital 15 years after implantation of a mitral valve prothesis with acute severe heart failure refractory to medical therapy. Ten days later she was referred for cardiological investigation and a missing mitral valve disc was diagnosed by echocardiography and right heart catheterization.

Inhibition of the uptake of nucleosides in cultured Harding-Passey melanoma cells by diflubenzuron.

Diflubenzuron (DFB) significantly inhibited the uptake of uridine, adenosine, and cytidine but not thymidine, in cultured Harding-Passey melanoma cells. Inhibition of nucleoside uptake was rapid (i.e.

[Influence of x-rays and quinacrine (atebrine) or chloroquine (resochine)--alone or in combination--on growth and melanin formation of Harding-Passey melanoma cells in monolayer culture].

Harding-Passey melanoma cells in monolayer culture (HPM-73 line) were treated during exponential growth phase with single doses of X-rays (85 kV) from 2 up to 16 Gy (200 to 1600 rd). While 2 or 4 Gy resulted in a growth retardation (up to 2 days) followed by resumption of proliferation thereafter, 8 Gy, and still more pronounced 16 Gy, resulted in a significant decrease of the survival rate (till about 5 to 10% after 8 Gy). In the course of several days after 8 or 16 Gy numerous large cells--in comparison with controls--were formed, and following exposure to 8 Gy the average cellular protein content had more than doubled (and after 16 Gy more than tripled) in the course of 11 days.