Publications by authors named "H B Hoh"
Article Synopsis
- Serum carcinoembryonic antigen (CEA) is indicated as a valuable prognostic biomarker for recurrence and survival in patients with early non-small cell lung cancer (NSCLC) after curative surgery.
- The study involved 18 patients with early-stage NSCLC, measuring their serum CEA levels before and after surgical resection over a follow-up period, revealing that 39% had elevated pre-operative CEA levels.
- Results showed that patients with a baseline CEA level above 5.0 ng/ml had significantly poorer disease-free survival compared to those with lower levels, underlining the potential of CEA to identify patients at risk for worse outcomes.
The properties and functions of chromophores utilized by nature are strongly affected by the environment formed by the protein structure in the cells surrounding them. This concept is transferred here to host-guest complexes with the encapsulated guests acting as an environmental stimulus. A new cyclophane host based on coronene bisimide is presented that can encapsulate a wide variety of planar guest molecules with binding constants up to (4.
View Article and Find Full Text PDFAqueous Zn-ion batteries (AZIBs), being safe, inexpensive, and pollution-free, are a promising candidate for future large-scale sustainable energy storage. However, in a conventional AZIBs setup, the Zn metal anode suffers oxidative corrosion, side reactions with electrolytes, disordered dendrite growth during operation, and consequently low efficiency and short lifespan. In this work, we discover that purging CO gas into the electrolyte could address these issues by eliminating dissolved O, inhibiting side reactions by buffering the local pH change, and preventing dendrite growth by inducing the in situ formation of a ZnCO solid electrolyte interphase layer.
View Article and Find Full Text PDFInterleukin-1 receptor-associated kinase 3 (IRAK3) is a pseudokinase mediator in the human inflammatory pathway, and ablation of its function is associated with enhanced antitumor immunity. Traditionally, pseudokinases have eluded "druggability" and have not been considered tractable targets in the pharmaceutical industry. Herein we disclose a CRISPR/Cas9-mediated knockout of IRAK3 in monocyte-derived dendritic cells that results in an increase in IL-12 production upon lipopolysaccharide (LPS) stimulation.
View Article and Find Full Text PDFAim: The COVID-19 pandemic has disrupted the delivery of healthcare to vulnerable older adults, prompting the expansion of telemedicine usage. This study surveyed the acceptance of virtual medical consultations among older adults and caregivers within geriatric outpatient services in a tertiary hospital during the pandemic.
Methods: A cross-sectional survey was conducted among caregivers and patients attending geriatric outpatient services in Kuala Lumpur, Malaysia.