Hippocampal Place Fields Maintain a Coherent and Flexible Map across Long Timescales.

To provide a substrate for remembering where in space events have occurred, place cells must reliably encode the same positions across long timescales. However, in many cases, place cells exhibit instability by randomly reorganizing their place fields between experiences, challenging this premise. Recent evidence suggests that, in some cases, instability could also arise from coherent rotations of place fields, as well as from random reorganization.

The Same Hippocampal CA1 Population Simultaneously Codes Temporal Information over Multiple Timescales.

It has long been hypothesized that a primary function of the hippocampus is to discover and exploit temporal relationships between events. Previously, it has been reported that sequences of "time cells" in the hippocampus extend for tens of seconds. Other studies have shown that neuronal firing in the hippocampus fluctuates over hours and days.

Memory creation and modification: Enhancing the treatment of psychological disorders.

Modification of the ongoing influence of maladaptive cognitive, emotional, and behavioral patterns is a fundamental feature of many psychological treatments. Accordingly, a clear understanding of the nature of memory adaptation and accommodation to therapeutic learning becomes an important issue for (1) understanding the impact of clinical interventions, and (2) considering innovations in treatment strategies. In this article, we consider advances in the conceptualization of memory processes and memory modification research relative to clinical treatment.

Publisher Correction: Viewpoints: how the hippocampus contributes to memory, navigation and cognition.

In the version of this article initially published, author Charan Ranganath's last name was misspelled Rangananth in the author list. Also, A. David Redish (redish@umn.

Viewpoints: how the hippocampus contributes to memory, navigation and cognition.

The hippocampus serves a critical function in memory, navigation, and cognition. asked John Lisman to lead a group of researchers in a dialog on shared and distinct viewpoints on the hippocampus. There has been a long history of studying the hippocampus, but recent work has made it possible to study the cellular and network basis of defined operations—operations that include cognitive processes that have been otherwise difficult to study (see Box 1 for useful terminology).