Micro-3D sculptured metastructures with deep trenches for sub-10 μm resolution.

Three-dimensional (3D) printing allows for the construction of complex structures. However, 3D-printing vertical structures with a high aspect ratio remains a pending challenge, especially when a high lateral resolution is required. Here, to address this challenge, we propose and demonstrate micro-3D sculptured metastructures with deep trenches of 1:4 (width:height) aspect ratio for sub-10 µm resolution.

Dual Type-II Colloidal Quantum Wells for Efficient Nonlinear Optical Limiting.

Colloidal II-VI nanocrystals have garnered significant research attention in nonlinear optical applications due to their low-cost synthesis, photophysical tunability, and ease of device integration. Herein, we report that dual-type II CdSe/CdTe/CdSe colloidal quantum wells (CQWs) with core/crown/crown structures achieve remarkable nonlinear optical limiting capabilities driven by an exceptionally large nonlinear absorption coefficient. Open aperture -scan reveals that these dual-type II CQWs exhibit a third-order nonlinear absorption coefficient of 33.

Impact of appetite stimulants on growth parameters in children with cystic fibrosis.

Objectives: Malnutrition is prevalent among children with cystic fibrosis (CF), often resulting from frequent pulmonary exacerbations and intestinal malabsorption. In addition to providing sufficient calorie intake through enteral formulas, appetite stimulants may help address nutritional deficiencies and improve overall prognosis.

Methods: This retrospective study included children who received cyproheptadine (CH) as an appetite stimulant for at least three consecutive months.

Prognostic value of IMDC score in non-small cell lung cancer receiving immunotherapy: old dog, new tricks? : IMDC in lung cancer immunotherapy.

Background: Although there are multiple treatment options, oncologists lack appropriate biomarkers for determining the efficacy and toxicity of immunotherapy. In this study, we aimed to use a combination of the clinical parameters of IMDC risk groups at the time of diagnosis to predict the effectiveness of immunotherapy.

Methods: This multicenter cross-sectional study retrospectively analyzed non-small cell lung cancer (NSCLC) patients receiving nivolumab for the prognostic effects of clinical factors, including the IMDC score.

Phage-inspired targeting of antibiotic-loaded polymeric micelles for enhanced therapeutic efficacy against monomicrobial sepsis.

The rapid increase in bacterial resistance to existing treatments underscores the critical need for novel therapeutic strategies. Here, an innovative approach using targeted nanocarrier systems that mimic phage-bacteria interactions through phage receptor binding protein (Gp45 from the ϕ11 lysogenic phage) or derived peptides (P1, P2, P3, P4, P5), are introduced. These nanodrugs, exhibited receptor-ligand specificity and strong binding affinity, for the first time, were employed for the precise delivery and targeting of antibiotics within living organisms.