Risk Factors for Progressive Disease After Immune Checkpoint Inhibitor Therapy in Head and Neck Squamous Cell Carcinoma.

Background: This study analyzed the clinical features of patients with recurrent or metastatic (R/M) head and neck squamous cell carcinoma (HNSCC), who developed progressive disease (PD) after immune checkpoint inhibitor (ICI) therapy.

Methods: We retrospectively analyzed 256 patients with R/M HNSCC treated with ICIs at 11 medical centers. Associations between the treatment outcomes-best response, overall survival, and progression-free survival-and various clinical factors were analyzed.

Varus/valgus angle of the femoral component relative to the tibial component increases risk of bearing dislocation in medial mobile bearing unicompartmental knee arthroplasty.

Background: In medial mobile-bearing unicompartmental knee arthroplasty (MB-UKA), the position of the bearing does not correspond to the planned position which will increasing the risk of bearing dislocation. This study aimed to explore the relationship between the malposition of the femoral and tibial components and the phenomenon of bearing deviation using postoperative radiological measurements.

Methods: One hundred twenty patients who underwent mobile-bearing uni-compartmental knee arthroplasty (MB-UKA) at our hospital between January and August 2023 were enrolled in this retrospective study.

Lightweight object detection model for food freezer warehouses.

Warehouses are critical logistics nodes, with food freezer warehouses playing a key role in ensuring food quality while facing challenges such as high-density item distribution and extremely low temperatures required for occupational safety. Traditional management methods struggle to meet these demands, underscoring the need for intelligent and digital solutions to improve efficiency and mitigate safety risks. This study proposes the YOLOv8-RSS model, a lightweight and high-precision approach tailored for food freezer warehouse scenarios.

Carbon tetrachloride does not promote hepatic fibrosis in ob/ob mice via downregulation of lipocalin-2 protein.

Although leptin-deficient ob/ob mice have been investigated to determine whether hepatic steatosis promotes susceptibility to hepatotoxic insults, carbon tetrachloride (CCl)-induced hepatic fibrosis in ob/ob mice remains largely unknown. In this study, we evaluate the pathogenic mechanisms of hepatic fibrosis in CCl-treated wild-type (WT) and ob/ob mice and analyze some parameters related to lipogenesis, inflammation, fibrosis, oxidative stress, apoptosis, and autophagy. CCl treatment attenuated liver weight and lipogenesis in ob/ob mice.

Genome-wide analysis of the SPL family in Zanthoxylum armatum and ZaSPL21 promotes flowering and improves salt tolerance in transgenic Nicotiana benthamiana.

Z. armatum is an economically valued crop known for its rich aroma and medicinal properties. This study identified 45 members of the SQUAMOSA-PROMOTER BINDING PROTEIN LIKE (SPL) gene family in the genome of Z.