- The study investigates how hemodialysis affects the oxygen-binding ability of hemoglobin (measured by p50) in patients with chronic kidney disease (CKD) and explores the relationship between p50 and various blood parameters.
- A total of 180 CKD patients were analyzed, dividing them into hemodialysis (HD) and non-hemodialysis (non-HD) groups, finding that HD patients required higher doses of erythropoietin but had similar hemoglobin levels compared to non-HD patients.
- Results indicated that non-HD patients experienced more severe metabolic acidosis and lower blood pH, while p50 values differed significantly between the two groups, suggesting a potential impact of dialysis on oxygen delivery
The study aimed to analyze patients with eosinophilic granulomatosis with polyangiitis (EGPA) from the POLVAS registry based on their ANCA status and when they were diagnosed, and compare them to patients with granulomatosis with polyangiitis (GPA) who have elevated eosinophil levels.
The results indicated that while ANCA-positive and ANCA-negative EGPA patients had similar clinical characteristics, ANCA-negative patients experienced more cardiovascular issues. Moreover, patients diagnosed before 2012 were generally younger and exhibited higher eosinophil counts and more frequent ENT and cardiovascular symptoms.
The researchers developed a model to differentiate between EGPA and GPA with elevated eosinophils, achieving high
The study aimed to assess the clinical complexity of chronic diseases like systemic lupus erythematosus (SLE) and ANCA-associated vasculitis (AAV) using the INTERMED Self-Assessment questionnaire (IMSA) to identify key contributing factors.
A total of 81 patients were evaluated through various questionnaires measuring biopsychosocial complexity, quality of life, mental state, and acceptance of illness.
The findings revealed that for SLE patients, lower mental health-related quality of life predicted higher clinical complexity, whereas in AAV patients, both low physical and mental health-related quality of life, along with depressive symptoms, were significant predictors of clinical complexity.
* Out of 129 RTRs studied, those with pruritus showed significantly higher NT-4 levels compared to those without, but BDNF levels were similar across groups.
* A positive correlation was found between NT-4 levels and the intensity of itching, suggesting NT-4 may play a role in CP among RTRs.
- The COVID-19 pandemic caused healthcare disruptions that affected chronically ill patients, leading to increased psychological stress and different coping strategies among them.
- A survey involving 398 patients with various chronic conditions revealed that most used problem-focused coping techniques, while self-blaming and avoidant coping were less common.
- Patients with neurological conditions, like multiple sclerosis, showed a riskier coping profile compared to those with kidney transplants, indicating a need for targeted mental health programs and early intervention for at-risk individuals.