Publications by authors named "H Auer"
Background And Objectives: Neuroimaging studies in patients with temporal lobe epilepsy (TLE) show widespread brain network alterations beyond the mesiotemporal lobe. Despite the critical role of the cerebrovascular system in maintaining whole-brain structure and function, changes in cerebral blood flow (CBF) remain incompletely understood in the disease. Here, we studied whole-brain perfusion and vascular network alterations in TLE and assessed its associations with gray and white matter compromises and various clinical variables.
View Article and Find Full Text PDFObjective: Temporal lobe epilepsy (TLE) is typically associated with pathology of the hippocampus, a key structure involved in relational memory, including episodic, semantic, and spatial memory processes. While it is widely accepted that TLE-associated hippocampal alterations underlie memory deficits, it remains unclear whether impairments relate to a specific cognitive domain or multiple ones.
Methods: We administered a recently validated task paradigm to evaluate episodic, semantic, and spatial memory in 24 pharmacoresistant TLE patients and 50 age- and sex-matched healthy controls.
Temporal lobe epilepsy (TLE) is the most common pharmaco-resistant epilepsy in adults. While primarily associated with mesiotemporal pathology, recent evidence suggests that brain alterations in TLE extend beyond the paralimbic epicenter and impact macroscale function and cognitive functions, particularly memory. Using connectome-wide manifold learning and generative models of effective connectivity, we examined functional topography and directional signal flow patterns between large-scale neural circuits in TLE at rest.
View Article and Find Full Text PDFCystic echinococcosis (CE) is a global health concern caused by cestodes, posing diagnostic challenges due to nonspecific symptoms and inconclusive radiographic results. Diagnosis relies on histopathological evaluation of affected tissue, demanding comprehensive tools. In this retrospective case study, Fourier transform infrared microscopy was explored for detecting and identifying CE through biochemical changes in human tissue sections.
View Article and Find Full Text PDFArticle Synopsis
- Echinococcus multilocularis is a parasitic cestode causing a deadly disease called alveolar echinococcosis, primarily spread by red foxes in Europe.
- The study investigated genetic diversity among E. multilocularis isolates from 19 European countries, analyzing 4,968 base pairs from five mitochondrial genes and identifying 43 different haplotypes.
- Findings indicated that most of the isolates shared four predominant haplotypes concentrated in mainland Europe, while Svalbard's isolates were genetically distinct, highlighting the need for more research in underrepresented eastern European regions to understand genetic variability.