Publications by authors named "H Ashizawa"
Feasibility of endoscopic resection for superficial laryngopharyngeal cancer after radiotherapy.
J Gastroenterol Hepatol
December 2024
Background And Aim: We aimed to elucidate the feasibility of endoscopic resection (ER) for salvage and metachronous lesions following chemoradiotherapy (CRT) and radiotherapy (RT) for laryngopharyngeal cancer.
Methods: Consecutive patients who underwent ER for superficial laryngopharyngeal cancer between March 2005 and September 2022 were retrospectively reviewed and stratified into salvage (16 patients, 16 lesions), metachronous (18 patients, 27 lesions), and naïve RT (217 patients, 306 lesions) groups. Salvage lesions were residual or local recurrent after CRT, and metachronous lesions were second primary lesions in the irradiated field following complete response.
Clarithromycin Modulates Neutrophilic Inflammation Induced by in Human Airway Epithelial Cells.
Antibiotics (Basel)
September 2024
Article Synopsis
- - The study investigates how periodontal pathogens cause severe inflammation by examining the role of neutrophils and the potential treatment effects of macrolides like clarithromycin on this inflammation.
- - Researchers tested clarithromycin on human airway epithelial cells exposed to pathogen supernatants, finding it reduced the production of the inflammatory marker IL-8 by interfering with specific signaling pathways.
- - Results suggest that the extracellular signal-regulated kinases (ERK) are activated by pathogen exposure and that clarithromycin pretreatment can inhibit this activation, pointing to its therapeutic potential for managing inflammation caused by periodontal pathogens in lung tissues.
Article Synopsis
- * Out of 672 patients analyzed, only 9 (1.3%) developed complicated NTM infections, leading to a higher mortality rate in those patients compared to others.
- * The findings suggest that while NTM complications are rare among those on biologics, they can be severe, especially in patients taking higher doses of corticosteroids, necessitating vigilant monitoring even in the absence of positive MAC antibody tests.
Background And Aim: Hot snare polypectomy using blend or coagulation current is widely used; however, it causes deeper tissue heat injury, leading to adverse events. We hypothesized that hot polypectomy using low-power pure cut current (PureCut, effect 1 10 W) could reduce deeper tissue heat injury. We conducted animal experiments to evaluate the deeper tissue heat injury and conducted a prospective clinical study to examine its cutting ability.
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- The study investigates whether patients with esophageal squamous cell carcinoma (ESCC) who have positive or unclear vertical margins after endoscopic submucosal dissection (ESD) should receive additional treatment.
- It analyzed patients treated from 2006 to 2018 with focus on those diagnosed with intralesional damage, evaluating the local recurrence risk after ESD.
- The findings showed no local recurrences among the evaluated patients (0%), suggesting that follow-up without further treatment may be an acceptable approach even when intralesional damage occurs.