Publications by authors named "H Asahara"
Considering the demand for organosulfur materials and the challenges associated with currently used oxidation processes, in this study, we evaluated the counter-cation of sodium chlorite (Na+ClO2-) with tetrabutylammonium chloride (Bu4N+Cl-) to synthesise tetrabutylammonium chlorite (Bu4N+ClO2-). Bu4N+ClO2- exhibited good solubility in organic solvents like chloroform (1.6 g mL-1) and ethyl acetate (0.
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- Basophils are rare immune cells that play vital roles in allergic reactions and defense against parasites, but how they activate and produce inflammation is not well understood, prompting research into RNA-binding proteins like tristetraprolin (TTP).
- Through various experiments, including RNA sequencing and mRNA stability assays on TTP-deficient mice, the study found that without TTP, basophils produce more inflammatory molecules and have prolonged mRNA stability for these mediators.
- The absence of TTP leads to increased allergic inflammation in a skin model, suggesting that targeting TTP could be a potential therapeutic approach for managing allergies.
Tendons and ligaments are crucial connective tissues linking bones and muscles, yet achieving full functional recovery after injury remains challenging. We investigated the characteristics of tendon stem/progenitor cells (TSPCs) by focusing on the declining tendon repair capacity with growth. Using single-cell RNA sequencing on Achilles tendon cells from 2- and 6-week-old mice, we identified and as novel surface antigen markers for TSPCs.
View Article and Find Full Text PDFTriple-negative breast cancer (TNBC) lacks the expression of hormone and HER2 receptors and is highly malignant with no effective therapeutic targets. In TNBC, the cancer stem-like cell (CSC) population is considered to be the main cause of resistance to treatment. Thus, the therapeutic targeting of this population could substantially improve patient survival.
View Article and Find Full Text PDFBackground: Microplastics (MPs), plastic particles < 5 mm in size, are prevalent in the environment, and human exposure to them is inevitable. To assess the potential risk of MPs on human health, it is essential to consider the physicochemical properties of environmental MPs, including polymer types, size, shape, and surface chemical modifications. Notably, environmental MPs undergo degradation due to external factors such as ultraviolet (UV) rays and waves, leading to changes in their surface characteristics.
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