Publications by authors named "H Arda"
Article Synopsis
- Identified noncoding driver mutations in pancreatic ductal adenocarcinoma (PDAC) by mapping accessible chromatin regions and histone modifications in pancreatic cell lines and tissues, integrating this data with whole-genome mutations from 506 PDAC cases.
- *From 3,614 noncoding somatic mutations (NCSMs) found, 178 were shown to significantly affect gene activity, highlighting their potential role in cancer progression.
- *Further experiments pinpointed specific genes impacted by these mutations, with a focus on one gene (KLF9) that showed reduced expression due to interference from NCSMs, establishing it as a possible PDAC driver gene.
Genetic and epigenetic variations in regulatory enhancer elements increase susceptibility to a range of pathologies. Despite recent advances, linking enhancer elements to target genes and predicting transcriptional outcomes of enhancer dysfunction remain significant challenges. Using 3D chromatin conformation assays, we generated an extensive enhancer interaction dataset for the human pancreas, encompassing more than 20 donors and five major cell types, including both exocrine and endocrine compartments.
View Article and Find Full Text PDFThe Hippo pathway plays a central role in tissue development and homeostasis. However, the function of Hippo in pancreatic endocrine development remains obscure. Here, we generated novel conditional genetically engineered mouse models to examine the roles of Hippo pathway-mediated YAP1/TAZ inhibition in the development stages of endocrine specification and differentiation.
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- - This study examined choroidal thickness in children with unilateral strabismic amblyopia using SD-EDI-OCT, comparing 25 affected children to 20 healthy peers to assess ocular differences.
- - Findings revealed that while the mean choroidal thickness in the amblyopic children was similar in both affected and fellow eyes, it was significantly thicker in both when compared to control eyes across various measurements.
- - A negative correlation was found between subfoveal choroidal thickness and axial length, but no links were established between thickness and age or visual acuity.
Cell type-specific enhancers are critically important for lineage specification. The mechanisms that determine cell-type specificity of enhancer activity, however, are not fully understood. Most current models for how enhancers function invoke physical proximity between enhancer elements and their target genes.
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