Publications by authors named "H Arakawa"
This is the English version of the 2024 clinical practice guidelines for the management of atopic dermatitis (AD). AD is a disease characterized by relapsing eczema with pruritus as a primary lesion. A crucial aspect of AD treatment is the prompt induction of remission via the suppression of existing skin inflammation and pruritus.
View Article and Find Full Text PDFWe investigated the carbonyl index (CI) of small microplastics (SMPs; 50-350 μm) and large microplastics (LMPs; >350 μm) in the surface waters of the Tokai region and Tokyo Bay in Japan. The degradation was evaluated by determining the CI from the infrared spectrum of microplastics (MPs) adopting the specified area under the band technique. Average CIs of SMPs and LMPs in polyethylene were 2.
View Article and Find Full Text PDFPurpose: The distribution of neutron ambient dose equivalent within the TrueBeam 10 MV photon chamber was investigated.
Materials And Methods: The research used particle and heavy ion transport code system (PHITS) code and JENDL-5.0 to simulate the neutron ambient dose equivalent on and around TrueBeam's head.
Article Synopsis
- - Excessive or insufficient levels of soluble uric acid (sUA) are linked to various health issues, while sUA at normal levels appears to be important for overall health, though its specific functions are not well understood.
- - This study shows that sUA can inhibit the enzyme CD38, which is involved in the breakdown of NAD, through a reversible non-competitive mechanism, particularly affecting purine metabolism.
- - At physiological levels, sUA may help to reduce systemic inflammation and peritonitis in mice, suggesting a significant role in regulating NAD availability and supporting the immune system by interacting with CD38.
Article Synopsis
- Nonalcoholic fatty liver disease (NAFLD) can lead to severe liver issues and the study investigated how palmitic acid (PA), a common dietary fat, affects liver cells using organ-on-a-chip technology.
- After exposure to palmitic acid, the liver cells showed a decrease in liver transcription factor activity and expression changes in 318 genes, indicating early signs of liver cell dedifferentiation.
- Despite these changes, there was no lipid accumulation in the cells, but an increase in collagen production was observed, suggesting that palmitic acid contributes to the early stages of lipotoxicity associated with NAFLD.