Characterization of PI3KCA and BRAF mutations in gastric adenocarcinoma: An approach to a personalized targeted therapy for Moroccan HER2 overexpressed patients.

Background And Study Aims: Targeted therapies have an increasing importance in digestive oncology. To our knowledge, we are the first to report the distribution of PI3KCA and BRAF mutations in Moroccan HER2 overexpressed patients, in order to introduce targeted therapy in the arsenal of therapeutic modalities for management in Morocco.

Patients And Methods: 98 gastric adenocarcinoma tissue samples were collected.

[Helicobacter pylori infection in 755 patients with digestive complaints: Pasteur Institute, Morocco, 1998-2007].

We determined the prevalence of Helicobacter pylori infection in 755 patients with digestive complaints identified from laboratory records at the Pasteur Institute, Morocco from 1998 to 2007. Epidemiological factors and gastrointestinal conditions associated with this infection were also studied. All patients underwent endoscopy and diagnosis was by histology examination.