Publications by authors named "H Alsaleh"

Background: Numerous studies have linked mitochondrial dysfunction to the development of type 2 diabetes (T2D) by affecting glucose-stimulated insulin secretion in pancreatic beta cells and reducing oxidative phosphorylation in insulin-responsive tissues. Given the strong genetic underpinnings of T2D, research has explored the connection between mitochondrial DNA haplogroups, specific variants, and the risk and comorbidities of T2D. For example, haplogroups F, D, M9, and N9a have been linked to an elevated risk of T2D across various populations.

View Article and Find Full Text PDF

Background: Falls among the older population have attracted global attention, with a specific emphasis on the regional contexts of falls. This study reports the incidence and characteristics of falls in the State of Kuwait, where there is currently no national fall prevention strategy.

Methodology: A prospective, cross-sectional study reported on 420 individuals aged 55 years and above admitted to Alrazi Orthopaedic Hospital in Kuwait City due to falls between March 2022 and February 2023.

View Article and Find Full Text PDF

Objective: The present study aimed to assess parental knowledge and awareness of early orthodontic consultation in children.

Methods: This cross-sectional study was conducted among parents of schoolchildren who were randomly selected from public schools in the Al Ahsa region of Saudi Arabia, using a convenience sampling technique. Data were collected using a prevalidated, pretested study questionnaire distributed to parents through the schoolchildren.

View Article and Find Full Text PDF

Purpose: Falls among older adults are a growing public health concern in Saudi Arabia. The Otago Exercise Program (OEP) is an evidence-based intervention aimed at reducing fall risk in this population. This study assessed the knowledge and attitudes of Saudi Arabian physical therapists toward the OEP and examined potential gender-based differences.

View Article and Find Full Text PDF
Article Synopsis
  • The study investigates the relationship between mitochondrial DNA (mtDNA) variants and obesity risk in Kuwaiti and Qatari populations, to address the high obesity prevalence in these regions.
  • Analysis of whole exome sequencing data from 1,112 participants identified haplogroup R as having a protective effect against obesity, with statistically significant results even after adjusting for age and sex.
  • While several mtDNA variants showed initial associations with obesity, they lost significance after further testing; the findings suggest haplogroup R could serve as a biomarker for obesity risk, warranting more research for confirmation.
View Article and Find Full Text PDF