Publications by authors named "H Alias"
Article Synopsis
- The study investigates how factors like genetics and clinical variability affect the pharmacokinetics of intravenous immunoglobulin (IVIG) treatment for immune disorders.
- It involved analyzing blood samples and clinical data from 79 patients across four Malaysian hospitals, using advanced modeling techniques to estimate pharmacokinetic parameters.
- The findings indicate that body weight is crucial for determining IVIG distribution and clearance, while the disease type also impacts how IVIG is distributed, but genetic variations in the FCGRT gene do not influence its pharmacokinetics.
Introduction: Impaired future fertility potential secondary to gonadotoxic therapies for childhood cancer is a shattering aftermath faced by childhood cancer survivors. Fertility preservation (FP) has emerged as a key to mitigate this unwelcomed sequelae. FP services catering to the needs of children and adolescents (C&A) population in developing countries are limited.
View Article and Find Full Text PDFBackground: The sexual interest of postmenopausal women is a crucial aspect of their overall well-being. Despite its importance, factors influencing postmenopausal sexual interest, particularly in Asian women, remain understudied and poorly understood.
Aims: To investigate the various factors influencing sexual interest in postmenopausal women in Malaysia.
Article Synopsis
- Leukaemia is the most common cancer in children, with a significant gap in knowledge regarding genomic changes in childhood acute myeloid leukaemia (AML) compared to adults, and relapsed AML remains a major cause of cancer deaths in young patients.
- The study conducted whole genome sequencing on samples from three patients at different stages (diagnosis, remission, and relapse) to understand the mutations involved in relapsed AML and validated findings with additional patient samples.
- The researchers identified 312 somatic mutations, with 35 new mutations appearing at relapse, including six potential driver mutations, notably recurrent mutations in the ETV6 gene, which lost its tumor-suppressive function, providing insights into the molecular mechanisms driving relapsed AML.
Purpose: There is no standardized best method on monitoring of patients with gestational diabetes on diet modification in the country. This study aims to investigate the optimum method of self-monitoring blood glucose.
Methods: This is a randomized clinical trial in a single tertiary centre involving patients with gestational diabetes mellitus (GDM) diagnosed based on NICE guideline on diet modification.