Stabilized Palladium Nanoparticles from Bis-(-benzoylthiourea) Derived-Pd Complexes as Efficient Catalysts for Sustainable Cross-Coupling Reactions in Water.

Stable palladium (II) complexes, incorporating a double (-benzoylthiourea) arrangement bonded to a complex heterocyclic scaffold, are used as precursors of catalytic species able to promote Suzuki-Miyaura, Mizoroki-Heck, Hiyama, Buchwald-Hartwig, Hirao and Sonogashira-Hagihara cross-coupling transformations in water. These sustainable processes are chemoselective and very versatile. The nanoparticles responsible for these catalytic reactions were analyzed and studied.

Recent insights about pyrrolidine core skeletons in pharmacology.

To overcome numerous health disorders, heterocyclic structures of synthetic or natural origin are utilized, and notably, the emergence of various side effects of existing drugs used for treatment or the resistance of disease-causing microorganisms renders drugs ineffective. Therefore, the discovery of potential therapeutic agents that utilize different modes of action is of utmost significance to circumvent these constraints. Pyrrolidines, pyrrolidine-alkaloids, and pyrrolidine-based hybrid molecules are present in many natural products and pharmacologically important agents.

Design, synthesis, biological evaluation and docking analysis of pyrrolidine-benzenesulfonamides as carbonic anhydrase or acetylcholinesterase inhibitors and antimicrobial agents.

The synthesis and biological assessment of novel multi-functionalized pyrrolidine-containing benzenesulfonamides were reported along with their antimicrobial, antifungal, CAs inhibition, and AChE inhibition as well as DNA-binding effects. The chemical structure of the compounds was elucidated by using FTIR, NMR, and HRMS. Compound , which had Ki values of 17.

Biological properties and conformational studies of amphiphilic Pd(II) and Ni(II) complexes bearing functionalized aroylaminocarbo--thioylpyrrolinate units.

A series of novel palladium(II) and nickel(II) complexes of multifunctionalized aroylaminocarbo--thioylpyrrolinates were synthesized and characterized by analytical and spectroscopic techniques. The biological properties of the freshly prepared compounds were screened against , , , , and bacteria and antituberculosis activity against H37Rv strains. Also, the antifungal activity was studied against , , and standard strains.

Subcritical water oxidation of 6-aminopenicillanic acid and cloxacillin using HO, KSO, and O.

This study was undertaken to investigate the degradation of 6-aminopenicillanic acid (6-APA) and cloxacillin in aqueous solution by the combined effect of subcritical water and the oxidising agents O, HO, and KSO. Nano ZnO was used as a solid catalyst. Response surface methodology was used to determine the optimum experimental parameters (temperature, treatment time, and concentration of oxidising agent).