Dural Closure Training With Prototyped Model.

Introduction: The hermetic closure of the dura mater is a critical step in neurosurgical training, often undervalued but crucial to preventing serious complications such as cerebrospinal fluid (CSF) leaks leading to meningitis and death. Inadequate closure, often due to insufficient training, can result in challenging complications, including prolonged hospitalization and reoperation.

Objective: To address the deficiencies in dural closure training, this study aims to describe a 3D prototype for simulating post-craniotomy dura mater suturing.

DARTS: an open-source Python pipeline for Ca microdomain analysis in live cell imaging data.

Ca microdomains play a key role in intracellular signaling processes. For instance, they mediate the activation of T cells and, thus, the initial adaptive immune system. They are, however, also of utmost importance for activation of other cells, and a detailed understanding of the dynamics of these spatially localized Ca signals is crucial for a better understanding of the underlying signaling processes.

Roadside vegetated filter strips to simultaneously lower stormwater pollution loadings and improve economics of biorefinery feedstocks.

Roadside vegetated filters strips (VFSs) reduce roadway runoff pollution by intercepting stormwater and reducing pollutant loads. VFS maintenance and operating costs can be reduced by designing the VFSs to serve as sites for production of marketable biomass. This biomass can provide feedstock for the emerging bioeconomy producing renewable fuels and biobased chemicals and products.

Techno-economic analysis of an integrated biorefinery to convert poplar into jet fuel, xylitol, and formic acid.

Background: The overall goal of the present study is to investigate the economics of an integrated biorefinery converting hybrid poplar into jet fuel, xylitol, and formic acid. The process employs a combination of integrated biological, thermochemical, and electrochemical conversion pathways to convert the carbohydrates in poplar into jet fuel, xylitol, and formic acid production. The C5-sugars are converted into xylitol via hydrogenation.

Hyperactivity is a Core Endophenotype of Elevated Neuregulin-1 Signaling in Embryonic Glutamatergic Networks.

The neuregulin 1 (NRG1) ErbB4 module is at the core of an "at risk" signaling pathway in schizophrenia. Several human studies suggest hyperstimulation of NRG1-ErbB4 signaling as a plausible pathomechanism; however, little is known about the significance of stage-, brain area-, or neural cell type-specific NRG1-ErbB4 hyperactivity for disease-relevant brain endophenotypes. To address these spatiotemporal aspects, we generated transgenic mice for Cre recombinase-mediated overexpression of cystein-rich domain (CRD) NRG1, the most prominent NRG1 isoform in the brain.