The fetal safety of hydrocortisone-pramoxine (Proctofoam-HC) for the treatment of hemorrhoids in late pregnancy.

Objective: Fetal safety has never been studied for any drug used in the treatment of hemorrhoids. Proctofoam-HC is a combination of a corticosteroid and a local anaesthetic that is proven effective for the treatment of hemorrhoids. The objective of this study was to assess prospectively the fetal safety of third trimester exposure to Proctofoam-HC.

The role of molecular microsatellite identity testing to detect sampling errors in prenatal diagnosis.

Objective: The objective was to determine the risk of sampling error in amniocentesis and chorionic villus sampling (CVS) in singleton and multiple pregnancies. Data from this and other published studies were used to discuss current practice guidelines for molecular identity testing.

Method: Clinical and laboratory records of all patients undergoing molecular-based identity testing in our clinical laboratory from July 2002 until March 2008 were reviewed.

The effectiveness of Proctofoam-HC for treatment of hemorrhoids in late pregnancy.

Objective: Currently no topical anti-hemorrhoidal agents have been studied for effectiveness in pregnancy. This study evaluated the effectiveness of Proctofoam-HC used during the last trimester of pregnancy.

Methods: In this prospective, open-label, observational study, pregnant women prescribed Proctofoam-HC were asked to complete two telephone interview questionnaires.

Uterine wall partial thickness necrosis following combined B-Lynch and Cho square sutures for the treatment of primary postpartum hemorrhage.

Background: Postpartum hemorrhage (PPH) is a significant factor in maternal morbidity and mortality. Successful techniques using compression sutures to control PPH have been described, in some cases using a combination of techniques. We describe a case in which compression sutures to control PPH were complicated by subsequent myometrial necrosis.

A randomized controlled trial of a bedside partogram in the active management of primiparous labour.

Objective: The partogram is a pictorial representation of the progress of labour, used in an effort to enhance early recognition of dystocia and help avoid Caesarean section (CS). The objective of this study was to evaluate the effect of partogram use on the CS and obstetric intervention rates.

Methods: We conducted a randomized controlled trial of use of the partogram in 1932 primiparous women with uncomplicated pregnancies at term.