Midsagittal MR measurements of the corpus callosum in healthy subjects and diseased patients: a prospective survey.

Purpose: To determine quantitatively a possible corpus callosum (CC) involvement in normal aging and white matter diseases.

Methods: Midsagittal size and signal of CC were recorded prospectively from 243 routine MR brain examinations. A midline internal skull surface (MISS) and subcutaneous fat signal intensity were measured to calculate CC/MISS and CC/fat ratios.