Bone scaffolds serve a crucial role in tissue engineering, particularly in facilitating bone regeneration where natural repair is insufficient. Despite advancements in the fabrication of polymeric bone scaffolds, the challenge remains to optimize their mechanical resilience. Specifically, research on the fatigue behaviour of polymeric bone scaffolds is scarce.
View Article and Find Full Text PDFThe bacterium Burkholderia pseudomallei is the cause of melioidosis infectious disease. In this bacterium, the BLF1 protein wide inhibits the synthesis of proteins in human cells. This disease is reported to cause a death rate of 40% in some parts of the world.
View Article and Find Full Text PDFBone scaffolds play a crucial role in bone tissue engineering by providing mechanical support for the growth of new tissue while enduring static and fatigue loads. Although polymers possess favourable characteristics such as adjustable degradation rate, tissue-compatible stiffness, ease of fabrication, and low toxicity, their relatively low mechanical strength has limited their use in load-bearing applications. While numerous studies have focused on assessing the static strength of polymeric scaffolds, little research has been conducted on their fatigue properties.
View Article and Find Full Text PDFWhile the mechanical performance of fused filament fabrication (FFF) parts has been extensively studied in terms of the tensile and bending strength, limited research accounts for their compressive performance. This study investigates the effect of four process parameters (layer height, extrusion width, nozzle temperature, and printing speed) on the compressive properties and surface smoothness of FFF parts made of Polylactic Acid (PLA). The orthogonal Taguchi method was employed for designing the experiments.
View Article and Find Full Text PDFThere is a significant demand for novel antibacterial agents against multidrug-resistant (MDR) gram-negative bacteria. Recently, probiotics have been noted for their antibacterial properties against various pathogens. This study aimed to investigate the effects of probiotic cell-free supernatants on MDR Pseudomonas aeruginosa.
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