Semaglutide for the management of diabesity: The real-world experience.

Background: Diabesity (diabetes as a consequence of obesity) has emerged as a huge healthcare challenge across the globe due to the obesity pandemic. Judicious use of antidiabetic medications including semaglutide is important for optimal management of diabesity as proven by multiple randomized controlled trials. However, more real-world data is needed to further improve the clinical practice.

Metabolic Dysfunction-Associated Fatty Liver Disease and Chronic Viral Hepatitis: The Interlink.

Metabolic dysfunction-associated fatty liver disease (MAFLD) has now affected nearly one-third of the global population and has become the number one cause of chronic liver disease in the world because of the obesity pandemic. Chronic hepatitis resulting from hepatitis B virus (HBV) and hepatitis C virus (HCV) remain significant challenges to liver health even in the 21st century. The co-existence of MAFLD and chronic viral hepatitis can markedly alter the disease course of individual diseases and can complicate the management of each of these disorders.

Analysis of Train-Track-Bridge Coupling Vibration Characteristics for Heavy-Haul Railway Based on Virtual Work Principle.

This paper introduces an innovative model for heavy-haul train-track-bridge interaction, utilizing a coupling matrix representation based on the virtual work principle. This model establishes the relationship between the wheel-rail contact surface and the bridge-rail interface concerning internal forces and geometric constraints. In this coupled system's motion equation, the degrees of freedom (DOFs) of the wheelsets in a heavy-haul train lacking primary suspension are interdependent.

-Mediated Mixed-Phase Synthesis and Characterization of Silver-Copper Oxide Nanocomposite for Environmental and Biological Applications.

() leaf extract was used as a reducing and stabilizing agent for the synthesis of silver-copper oxide nanocomposite (Ag-CuO NC). Scanning and transmission electron microscopies (SEM and TEM) were used to examine the structural morphology, and the average particle size was determined to be 47.65 nm.

Variable neighborhood search to solve the vehicle routing problem for hazardous materials transportation.

This work focuses on the Heterogeneous Fleet Vehicle Routing problem (HFVRP) in the context of hazardous materials (HazMat) transportation. The objective is to determine a set of routes that minimizes the total expected routing risk. This is a nonlinear function, and it depends on the vehicle load and the population exposed when an incident occurs.