Spontaneous Rupture of Uterine Vessels in the Third Trimester of Pregnancy Resulting in Severe Hemoperitoneum and Fetal Death: A Case Report and Literature Review.

Spontaneous hemoperitoneum during pregnancy, caused by rupture of uterine vessels, is a rare and dangerous complication that can lead to maternal and foetal death. We presented a case of a 25-year-old primigravid woman with severe abdominal pain, distension, and hemodynamic instability at 33 weeks of gestation. An ultrasound and computed tomography scan of the abdomen and pelvis revealed intraperitoneal fluid collection with a non-viable intrauterine pregnancy.

TLR and TNF-R1 activation of the MKK3/MKK6-p38α axis in macrophages is mediated by TPL-2 kinase.

Previous studies suggested that Toll-like receptor (TLR) stimulation of the p38α MAP kinase (MAPK) is mediated by transforming growth factor-β-activated kinase 1 (TAK1) activation of MAPK kinases, MKK3, MKK4 and MKK6. We used quantitative mass spectrometry to monitor tumour progression locus 2 (TPL-2)-dependent protein phosphorylation following TLR4 stimulation with lipopolysaccharide, comparing macrophages from wild-type mice and Map3k8(D270A/D270A) mice expressing catalytically inactive TPL-2 (MAP3K8). In addition to the established TPL-2 substrates MKK1/2, TPL-2 kinase activity was required to phosphorylate the activation loops of MKK3/6, but not of MKK4.

[Palmoplantar keratoderma: a rare manifestation of myxoedema].

Background: Herein we report a rare case of acquired palmoplantar keratoderma in association with myxoedema and hypothyroidism.

Patients And Methods: A 53-year-old woman presented with palmoplantar keratoderma, dry skin, muscular weakness and cramps for 9 months. The laboratory work-up revealed autoimmune thyroiditis with hypothyroidism.