Publications by authors named "H Abdesselem"
Introduction: Type 2 diabetes (T2D) is a prevalent metabolic disorder linked to chronic inflammation and endothelial dysfunction, which contributes to the development of microvascular complications (MVCs) such as diabetic retinopathy (DR) and diabetic neuropathy (DN). Genetic factors, including variations in the ABO gene, may influence these complications. This study aimed to investigate the association between the ABO rs2073823 polymorphism and the risk of MVCs in patients with T2D, as well as its impact on inflammatory biomarkers, endothelial markers, and lipid profiles.
View Article and Find Full Text PDFBackground: Autism spectrum disorder (ASD) is a neurodevelopmental disorder characterized by symptoms that include social interaction deficits, language difficulties and restricted, repetitive behavior. Early intervention through medication and behavioral therapy can eliminate some ASD-related symptoms and significantly improve the life-quality of the affected individuals. Currently, the diagnosis of ASD is highly limited.
View Article and Find Full Text PDFComparison of clinical characteristics, microvascular complications and inflammatory markers in type 2 diabetic patients under insulin versus metformin treatment: A cross-sectional study at Karbala Diabetic Center, Iraq.
Medicine (Baltimore)
November 2024
Article Synopsis
- - Type 2 diabetes mellitus (T2DM) is a widespread health problem linked to chronic inflammation, which worsens the disease and leads to complications like cardiovascular issues.
- - A study involving 522 diabetes patients compared the effects of insulin and metformin on inflammatory markers and complications, revealing that insulin users had significantly higher rates of microvascular problems like retinopathy and neuropathy compared to those on metformin.
- - Results showed that insulin treatment lowered certain inflammatory markers (TNF-α and IL-6) but increased adhesion molecules (sE-selectin and sP-selectin), while metformin showed different inflammatory profiles, suggesting that treatment choices could influence disease progression differently.
Autism spectrum disorder (ASD) is a neurodevelopmental disorder characterized by impaired social interaction and communication, as well as the occurrence of stereotyped and repetitive behaviors. Previous studies have provided solid evidence of dysregulated immune system in ASD; however, limited studies have investigated autoantibody profiles in individuals with ASD. This study aims to screen plasma autoantibodies in a well-defined cohort of young children with ASD (n = 100) and their matched controls (n = 60) utilizing a high-throughput KoRectly Expressed (KREX) i-Ome protein-array technology.
View Article and Find Full Text PDFIntroduction-aim: Flexible insulin therapy is currently considered the gold standard therapy of type 1 diabetes. We aimed to study the evolution of glycemic control, weight and nutritional intake of a group of patients with type 1 diabetes, three months after the initiation of functional insulin therapy (FIT).
Methods: This was a prospective longitudinal study having included 30 type 1 diabetic patients hospitalized for education to FIT.