Phytochemical, Cytoprotective Profiling, and Anti-Inflammatory Potential of in Rheumatoid Arthritis: An Experimental and Simulation Study.

Background: Rheumatoid arthritis (RA) is a chronic autoimmune disorder characterized by severe pain, inflammation, and joint deformity. Currently, it affects 1% of the population, with a projection to exceed 23 million cases by 2030. Despite significant advancements, non-steroidal anti-inflammatory drugs (NSAIDs), the first line of treatment, are associated with a range of adverse effects.

Temporal dynamics of neonatal hypoxic-ischemic encephalopathy injuries on magnetic resonance imaging.

Moderate to severe perinatal hypoxic-ischemic encephalopathy occurs in ~ 1 to 3/1000 live births in high-income countries and is associated with a significant risk of death or neurodevelopmental disability. Detailed assessment is important to help identify high-risk infants, to help families, and to support appropriate interventions. A wide range of monitoring tools is available to assess changes over time, including urine and blood biomarkers, neurological examination, and electroencephalography.

Challenges of Faith Community Nursing in a Midwestern Healthcare System.

Faith community nurses are positioned to play a vital role in addressing whole person health in multiple settings. A steady decline of nurses completing faith community nurse (FCN) training in a midwestern healthcare system sparked the system's hospital leadership to re-evaluate the FCN training and outreach program. To inform future education programs, an online needs assessment survey was deployed to FCNs.

Drug Repurposing Using Hypergraph Embedding Based on Common Therapeutic Targets of a Drug.

Developing a new drug is a long and expensive process that typically takes 10-15 years and costs billions of dollars. This has led to an increasing interest in drug repositioning, which involves finding new therapeutic uses for existing drugs. Computational methods become an increasingly important tool for identifying associations between drugs and new diseases.

Incentive-linked prescribing and the plights of patients: a qualitative study in Pakistan.

Objective: To examine the perceived impact of incentive-linked prescribing (ILP) on the everyday lives of patients in Pakistan.

Methods: Adopting a qualitative approach, in-depth interviews were conducted with 26 patients in Karachi. A convenient sampling method was used to recruit patients from different pharmacies located in all six districts of Karachi namely East, West, South, Central, Korangi, and Malir.