CD47 and CD68 expression in breast cancer is associated with tumor-infiltrating lymphocytes, blood vessel invasion, detection mode, and prognosis.

CD47 expressed on tumor cells binds to signal regulatory protein alpha on macrophages, initiating inhibition of phagocytosis. We investigated the relationships between tumor expression of CD47 and CD68 macrophage content, subsets of tumor-infiltrating lymphocytes (TILs), and vascular invasion in breast cancer. A population-based series of 282 cases (200 screen detected and 82 interval patients) from the Norwegian Breast Cancer Screening Program was examined.

Historical glacier change on Svalbard predicts doubling of mass loss by 2100.

The melting of glaciers and ice caps accounts for about one-third of current sea-level rise, exceeding the mass loss from the more voluminous Greenland or Antarctic Ice Sheets. The Arctic archipelago of Svalbard, which hosts spatial climate gradients that are larger than the expected temporal climate shifts over the next century, is a natural laboratory to constrain the climate sensitivity of glaciers and predict their response to future warming. Here we link historical and modern glacier observations to predict that twenty-first century glacier thinning rates will more than double those from 1936 to 2010.

Tumor-associated lymphocytes and macrophages are related to stromal elastosis and vascular invasion in breast cancer.

The tumor microenvironment plays a critical role in breast cancer progression. Here, we investigated tumor-infiltrating lymphocytes (TILs) and associations with macrophage numbers, tumor stromal elastosis, vascular invasion, and tumor detection mode. We performed a population-based retrospective study using data from The Norwegian Breast Cancer Screening Program in Vestfold County (2004-2009), including 200 screen-detected and 82 interval cancers.

Fibulin-2 expression associates with vascular invasion and patient survival in breast cancer.

Stromal elastosis is related to good prognosis in breast cancer and fibulin-2 helps to stabilize elastic fibers in basement membranes. Here, we examined the level of perivascular fibulin-2 expression in relation to elastosis content, vascular invasion, molecular subtypes, tumour detection mode, and patient prognosis in breast cancer. We performed a population based retrospective study of invasive breast cancers from the Norwegian Breast Screening Program (Vestfold County, 2004-2009) including 200 screen-detected and 82 interval cancers.