Publications by authors named "H A W van Onzenoort"
Background: Guidelines advise 50 % and 25 % dose reduction of the therapeutic nadroparin dose (86 IU/kg) in patients with eGFR 15-29 and 30-60 ml/min respectively. For monitoring, peak anti-Xa levels are suggested. Data lack whether this results in therapeutic anti-Xa levels or in anti-Xa levels that are comparable to those of patients without renal impairment.
View Article and Find Full Text PDFBackground: Outpatient Parenteral Antimicrobial Therapy (OPAT) is considered a patient-friendly and cost-effective practice. Patients in the OPAT service can be at risk for developing adverse events. Due to extensive variations in practice, guidelines have been developed to minimize the risks.
View Article and Find Full Text PDFArticle Synopsis
- - Vancomycin is an essential antibiotic for treating serious infections like MRSA, but it needs careful monitoring to avoid side effects and ensure effectiveness due to its narrow therapeutic range.
- - Researchers developed a quick and efficient method using UPLC-MS/MS to measure vancomycin and creatinine in dried blood spots (DBS), which is less invasive than traditional blood sampling.
- - The validation showed that this method can accurately measure the drug and creatinine levels with high precision and minimal errors, making it suitable for clinical use.
Objective: To examine the effect on adherence to disease modifying anti-rheumatic drugs (DMARDs) in participants with rheumatoid arthritis (RA) of a serious game that targeted implicit attitudes toward medication.
Methods: A multicentre randomised controlled trial (RCT) was performed with adults with RA that used DMARDs and possessed a smartphone/tablet. Control and intervention groups received care as usual.
Purpose: The effect of self-administration of medication (SAM), in which capable hospitalized patients administer medication themselves on medication self-efficacy is inconclusive. The aim of this study was to evaluate the effect of SAM on medication self-efficacy, adherence and patient satisfaction.
Patients And Methods: A prospective pre-post intervention study on the orthopedic ward of the Sint Maartenskliniek (Nijmegen) was conducted from January 2020 to July 2021.