[Second edition of the Diagnostic compass].

The second edition of the Diagnostic compass once more aims at contributing to rational use of accessory diagnostic techniques. The target group of the book consists of all physicians directly or indirectly involved in diagnosing patients clinical chemists and--from this second edition onwards--senior medical students. The number of clinical problems in the first part of the book is extended from 111 to 229.

The effects of continuous combined transdermal oestrogen-progestogen treatment on bleeding patterns and the endometrium in postmenopausal women.

Fifty postmenopausal women requiring hormone replacement therapy for the treatment of climacteric symptoms were recruited in six centers. All patients received a new combined norethisterone acetate (NETA)/oestradiol (E2)-TTS, (Estragest TTS, Ciba-Geigy Ltd), delivering 0.25 mg NETA and 50 micrograms E2 per day, continuously for 12 calendar months.

The flush revisited.

A nadir of LH precedes the onset of the flush and a flush is never seen without an LH pulse. However, after surgical and medical (GnRH agonist) hypophysectomy flushing occurs while LH is absent, thus LH itself is not the cause of the flush. GnRH agonist treatment induces low LH, whereas flushes remain, even when oestrogens are supplemented, suggesting that GnRH itself is the mediator.

Impact of different GnRH analogs in benign gynecological disorders related to their chemical structure, delivery systems and dose.

This review addresses the question of whether the different gonadotropin releasing hormone (GnRH) agonists in clinical use might have different impacts, related to their chemical structure, delivery system and dose. Impact was investigated in benign gynecological disorders, i.e.