Effect of toxic thioureas on resistance of rats to growth in the lungs of intravenously and intratracheally seeded tumour cells.

Clonogenic growth (colony-forming efficiency, CFE) of i.v. injected allogeneic W256 tumour cells in the lungs was markedly enhanced by treatment of rats with alpha-naphthyl thiourea (ANTU) injected i.

Functional integrity and inflammatory reactions of exchange vessels and lymphatics in X-irradiated tissues.

Local pre-irradiation of the foot (LFI) with 500 to 20,000 rad X-rays and sublethal whole body irradiation (WBI) of rats did not significantly affect development, intensity or resolution of inflammatory oedema induced by subdermal injection of the foot with pharmacological mediators of inflammation or Compound 48/80. LFI and WBI both caused modest increases in swelling induced by carrageenan which are attributed to a combined (additive) effect of slight early oedema from increased vascular permeability induced by radiation and the inflammatory oedema induced by carrageenan. Age of rat did not significantly affect inflammatory oedema induced by various irritants in unirradiated or irradiated rats.

Reactions of the tumour bed to lethally irradiated tumour cells, and the Révész effect.

Subdermal inoculation of the foot of the rat with lethally irradiated (LI) Walker tumour (W256) cells, mixed with viable (V) W256 cells, decreased the latent period for initiation of allogeneic tumour growth without significantly affecting its rate. This Révész effect decreased with increase in the number of inoculated V cells, and with decrease in age of recipient. LI cells of a different (Y-P388) rat tumour exerted a Révész effect, even in recipients which had been immunized with LI (Y-P388) tumour cells.